Publications-Xiaomin Jiang Lab

Tillman L#, Jiang X#, Wang C, Xiong Y, Lin W*

44. Low-Dose X-Ray Radiation Enhances Intratumoral Accumulation and Antitumor Effects of Nanoscale Coordination Polymers via Neutrophil-Mediated Trafficking.

Adv. NanoBiomed Res. 2025, 250008

Mao Y, Tillman L, Jiang X, Bian W, Wang C, Fromme T, Weichselbaum R R, Lin W*

43. Light-triggered toll-like receptor activation in a nanoscale metal–organic framework for synergistic PDT and cancer immunotherapy.

Chem. Sci., 2025, Accepted.

Nash G T, Zhen W, Li J, Jiang X, Wang C, Weichselbaum R R, Lin W*

42. Azidothymidine Phosphate-Loaded Hafnium-Phthalocyanine Nanoscale Metal–Organic Framework for Enhanced Cancer Therapy.

Chem. Mater. 2025, Accepted.

Zhen W#, Jiang X#, Li E, Lee M J, Luo T, Germanas T, Weichselbaum R R* Lin W*

41. Remodeling Replicative Immortal Tumors into an Immunogenic and Vulnerable Phenotype via Nanoscale Coordination Polymers Mediated Cell-Senescence.

Biomaterials. 2025, 322, 123355

Bian W#, Jiang X#, Li J, Tillman L, Wang C, Zhen W, Weichselbaum R R, Fromme T* Lin W*

40. Metal-Organic Layer Delivers 3-Bromopyruvate to Mitochondria for Metabolic Regulation and Cancer Radio-Immunotherapy.

Chem. Sci., 2025,16, 5234-5240

Jiang X, Lin W*

39. Innate Immune Activation with Multifunctional Nanoparticles for Cancer Immunotherapy.

Angew. Chem. Int. Ed. 2025, 64, e202423280

Liu J, Zhao Z, Zanni R, Jiang X, Weichselbaum R R, Lin W*

38. Nanoparticle-Mediated Toll-Like Receptor Activation and Dual Immune Checkpoint Downregulation for Potent Cancer Immunotherapy.

ACS Nano 2025, 19, 9, 8852–8866

Ma X#, Jiang X#, Wang Z#, Fan Y, Li J, Chow C, Wang C, Deng C, Lin W*

37. Cationic Metal-Organic Layer Delivers siRNAs to Overcome Radioresistance and Potentiate Cancer Radiotherapy.

Angew. Chem. Int. Ed. 2024, e202419409

Wang C#, Li J#, Jiang X#, Ma X, Zhen W, Tillman L, Weichselbaum R R* Lin W*

36. Bifunctional Metal‐Organic Framework Synergistically Enhances Radiotherapy and Activates STING for Potent Cancer Radio‐Immunotherapy.

Angew. Chem. Int. Ed. 2024, e202417027

Jiang X, Luo T, Yang K, Lee M J, Liu J, Tillman L, Zhen W, Weichselbaum R R, Lin W*

35. Nanoparticle-induced STING activation disrupts tumor vasculature to overcome the EPR limitation and increase drug deposition for tumor eradication.

Sci. Adv. 2024, 10, eado0082

Luo T#, Jiang X#, Fan Y, Yuan E, Li J, Tillman L, Lin W*

34. STING Agonist-Conjugated Metal-Organic Framework Induces Artificial Leukocytoid Structures and Immune Hotspots for Systemic Antitumor Responses.

Natl. Sci. Rev. 2024, 10, nwae167

Luo T#, Jiang X#, Li J#, Nash G T, Yuan E, Albano L, Tillman L, Lin W*

33. Phosphate Coordination to Metal-Organic Layer Secondary Building Units Prolongs Drug Retention for Synergistic Chemoradiotherapy.

Angew. Chem. Int. Ed. 2024, e202319981

Liu J#, Jiang X#, Li Y, Yang K, Weichselbaum R R* Lin W*

32. Immunogenic Bifunctional Nanoparticle Suppresses PD-L1 Expression in Tumor and Dendritic Cells to Elicit Adaptive Immunity and Potent Chemo-Immunotherapy.

ACS Nano 2024, 18, 6, 5152–5166

Xiong Y, Li J, Jiang X, Zhen W, Ma X, Lin W*

31. Nitric Oxide-Releasing Nanoscale Metal-Organic Layer Overcomes Hypoxia and Reactive Oxygen Species Diffusion Barriers to Enhance Cancer Radiotherapy.

Adv. Sci. 2024, 2413518

Zhen W, Xu Z, Mao Y, McCleary C, Jiang X, Weichselbaum R R, Lin W*

30. Nanoscale Mixed-Ligand Metal-Organic Framework for X-ray Stimulated Cancer Therapy.

J. Am. Chem. Soc. 2024, 146, 48, 33149-33158

Lin G, Tillman L, Luo T, Jiang X, Fan Y, Liu G, Lin W*

29. Nanoscale Metal-Organic Layer Reprograms Cellular Metabolism to Enhance Photodynamic Therapy and Antitumor Immunity.

Angew. Chem. Int. Ed. 2024, e202410241

Liu J, Kang DW, Fan Y, Nash GT, Jiang X, Weichselbaum R R, and Lin W*

28. Nanoscale Covalent Organic Framework with Staggered Stacking of Phthalocyanines for Mitochondria-Targeted Photodynamic Therapy.

J. Am. Chem. Soc. 2024, 146, 1, 849–857

Jiang X, Liu J, Lee MJ, Peng C, Luo T, Tillman L, Zhen W, Weichselbaum R R, Lin W*

27. Nanoscale Coordination Polymer Synergizes Photodynamic Therapy and Toll-Like Receptor Activation for Enhanced Antigen Presentation and Antitumor Immunity.

Biomaterials 2023, 302, 122334

Jiang X, Luo T, Lee MJ, Liu J, Tillman L, Zhen W, Weichselbaum R R, Lin W*

26. Co-delivery of Three Synergistic Chemotherapeutics in A Core-Shell Nanoscale Coordination Polymer for the Treatment of Pancreatic Cancer.

Biomaterials 2023, 301, 122235

Jiang X, Liu J, Mao J, Han W, Fan Y, Luo T, Xia J, Lee M J, Lin W*

25. Pharmacological ascorbate potentiates combination nanomedicines and reduces cancer cell stemness to prevent post-surgery recurrence and systemic metastasis.

Biomaterials 2023, 295, 122037

Liu J#, Jiang X#, Li Y, Yang K, Weichselbaum R R* Lin W*

24. A Three-in-One Nanoscale Coordination Polymer for Potent Chemo-Immunotherapy.

Small Method. 2023, 2201437

Xu Z, Zhen W, McCleary C, Luo T, Jiang X, Peng C, Weichselbaum R R, and Lin W*

23. Nanoscale Metal-Organic Framework with an X-ray Triggerable Prodrug for Synergistic Radiotherapy and Chemotherapy.

J. Am. Chem. Soc. 2023, 145, 18698-18704

Zhen W, Luo T, Wang Z, Jiang X, Yuan E, Weichselbaum R R, Lin W*

22. Mechanoregulatory Cholesterol Oxidase‐Functionalized Nanoscale Metal–Organic Framework Stimulates Pyroptosis and Reinvigorates T Cells.

Small 2023, 2305440

Luo T, Fan Y, Mao J, Jiang X, Albano L, Yuan E, Germanas T, Lin W*

21. Metal-Organic Layer Delivers 5-Aminolevulinic Acid and Porphyrin for Dual-Organelle-Targeted Photodynamic Therapy.

Angew. Chem. Int. Ed. 2023, 62, e202301910

Yang K#, Han W#, Jiang X#, Piffko A, Bugno J, Han C, Li S, Xu Z, Zheng W, Wang L, Liang H, Ting JPY, Fu YX, Lin W* Weichselbaum R R*

20. Zinc-c-di-AMP Nanoparticles Target and Suppress Tumors via Endothelial STING Activation and Tumor Associated Macrophage Reinvigoration.

Nat. Nanotechnol. 2022, 17, 1322-1331

Jiang X, Han W, Liu J, Mao J, Lee MJ, Rodriguez M, Li Y, Luo T, Xu Z, Yang K, Bissonnette M, Weichselbaum R R, Lin W*

19. Tumor-Activatable Nanoparticles Target Low-Density Lipoprotein Receptor to Enhance Drug Delivery and Antitumor Efficacy.

Adv. Sci. 2022, 2201614

Jiang X, Liu J, Lee MJ, Xia J, Luo T, Rodriguez M, Lin W*

18. Two-stage Release of SN38 from a Core-shell Nanoparticle Enhances Tumor Deposition and Antitumor Efficacy for Synergistic Combination with Immune Checkpoint Blockade.

ACS Nano 2022, 16, 21417–21430

Li Y#, Jiang X#, Luo T, Xia J, Lee MJ, Weichselbaum R R, Lin W*

17. TLR3 Agonist Nanoscale Coordination Polymer Synergizes with Immune Checkpoint Blockade for Immunotherapy of Cancer.

Biomaterials 2022, 290, 121831

Luo T, Nash GT, Jiang X, Feng X, Mao J, Liu J, Juloori A, Pearson A T, Lin W*

16. A 2D Nanoradiosensitizer Enhances Radiotherapy and Delivers STING Agonists to Potentiate Cancer Immunotherapy.

Adv. Mater. 2022, 34, 2110588

Jiang X, He C and Lin W*

15. Supramolecular Metal-based Nanoparticles for Drug Delivery and Cancer Therapy.

Curr. Opin. in Chem. Biol., 2021, 61, 143-153

Ling X#, Han W#, Jiang X#, Rodriguez M, Zhu P, Wu T, Lin W*

14. Point-source Burst of Coordination Polymer Nanoparticles for Tri-modality Cancer Therapy.

Biomaterials 2021, 270, 120690

Ling X, Jiang X, Li Y, Han W, Rodriguez M, Xu Z, Lin W*

13. Sequential Treatment of Bioresponsive Nanoparticles Elicits Antiangiogenesis and Apoptosis and Synergizes with a CD40 Agonist for Antitumor Immunity.

ACS Nano 2021, 15, 765-780

Luo T, Nash GT, Xu Z, Jiang X, Liu J, Lin W*

12. Nanoscale metal–organic framework confines zinc-phthalocyanine photosensitizers for enhanced photodynamic therapy.

J. Am. Chem. Soc. 2021, 143, 34, 13519–13524

Li Y, Han W, He C, Jiang X, Fan Y, Lin W*

11. Nanoscale coordination polymers for combined chemotherapy and photodynamic therapy of metastatic cancer.

Bioconjugate Chem. 2021, 32, 2318-2326

Shi W, Quan Y, Lan G, Ni K, Song Y, Jiang X, Wang C, Lin W*

10. Bifunctional metal–organic layers for tandem catalytic transformations using molecular oxygen and carbon dioxide.

J. Am. Chem. Soc. 2021, 143, 40, 16718–16724

Quan Y, Shi W, Song Y, Jiang X, Wang C, Lin W*

9. Bifunctional metal–organic layer with organic dyes and iron centers for synergistic photoredox catalysis.

J. Am. Chem. Soc. 2021, 143, 8, 3075–3080

Ni K, Luo T, Culbert A, Kaufmann M, Jiang X, Lin W*

8. Nanoscale Metal–Organic Framework Co-delivers TLR-7 Agonists and Anti-CD47 Antibodies to Modulate Macrophages and Orchestrate Cancer Immunotherapy.

J. Am. Chem. Soc. 2020 142, 12579-12584

Ni K, Luo T, Lan G, Culbert A, Song Y, Wu T, Jiang X, Lin W*

7. A Nanoscale Metal–Organic Framework to Mediate Photodynamic Therapy and Deliver CpG Oligodeoxynucleotides to Enhance Antigen Presentation and Cancer Immunotherapy.

Angew. Chem. Int. Ed. 2020, 59, 1108

Luo T, Ni K, Culbert A, Lan G, Li Z, Jiang X, Kaufmann M, Lin W*

6. Nanoscale Metal-Organic Frameworks Stabilize Bacteriochlorins for Type I and Type II Photodynamic Therapy.

J. Am. Chem. Soc. 2020 142, 7334-7339

Quan Y, Lan G, Shi W, Xu Z, Fan Y, You E, Jiang X, Wang C, Lin W*

5. Metal–organic layers hierarchically integrate three synergistic active sites for tandem catalysis

Angew. Chem. Int. Ed. 2020, 133, 3152-3157

Quan Y, Song Y, Shi W, Xu Z, Chen JS, Jiang X, Wang C, Lin W*

4. Metal–organic framework with dual active sites in engineered mesopores for bioinspired synergistic catalysis.

J. Am. Chem. Soc. 2020, 142, 8602–8607

Lan G, Ni K, You E, Wang M, Culbert A, Jiang X, Lin W*

3. Multifunctional nanoscale metal–organic layers for ratiometric pH and oxygen sensing.

J. Am. Chem. Soc. 2019, 141, 18964–18969

Lan G, Quan Y, Wang M, Nash GT, You E, Song Y, Veroneau SS, Jiang X, Lin W*

2. Metal–organic layers as multifunctional two-dimensional nanomaterials for enhanced photoredox catalysis.

J. Am. Chem. Soc. 2019, 141, 15767–15772

Pan W, Mao L, Shi M, Fu Y, Jiang X, Feng W, He Y, Xu D, Yuan L*.

1. The cytochrome c–cyclo[6]aramide complex as a supramolecular catalyst in methanol.

New J. Chem., 2018, 42, 3857-3866

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Email: jiangxiaomin@westlake.edu.cn
Lab: E4-310, Yungu Campus, Weatlake University
Address: No. 600 Dunyu Road, Xihu District, Zhejiang, 310030, P. R. China
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